Reticuloendothelial system- Formation,Classification

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 RETICULOENDOTHELIAL SYSTEM

  • Reticuloendothelial system is also known as mononuclear phagocytic system

FORMATION:

  • Bone marrow ,monocyte circulate in blood for 3 days they attain maturity,ability to phagocytose gets converted to macrophage -tissue macrophage gets scattered in different body parts and collectively called "tissue-macrophage system'.

FOUND IN:

1)Endothelial lining of vascular and lymph node
2)Connective tissue and some organ like spleen ,liver,lungs,lymph node etc.



CLASSIFICATION:

1) FIXED RETICULOENDOTHELIAL CELLS
2)WANDERING CELL 

1) FIXED RETICULOENDOTHELIAL CELLS:

  • Location- tissue
Found in :
  • Connective tissue : serous membrane of pleura
  • Endothelium of blood of sinusoid; liver,spleen,lymph node
  • Reticulum; spleen,lymph node 
  • Central nervous system :microglia
  • Lungs: alveoli of lungs 

2) WANDERING CELL:

A)IN BLOOD:
  • NEUTROPHIL
  • MONOCYTE
B)IN SOLID TISSUE 
  • Only during emergency
  • Connective tissue and other organs come to play 

FUNCTION:

1)Role in inflammation and healing
2)Role in defense against bacteria
3) Role in immune response
4)Role in removal of old RBCs,WBCs and platelet.





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