RIFAMPICIN :

Its a semi-synthetic derivative of Rifamycin
1st line drug used in tuberculosis
Rifampicin is bactericidal to M.tuberculosis,M.leprae
Inhibits most gram positive and gram negative bacteria like staphylococcus aureus,N.meningitidis,E.coli,klebsiella,pseudomonas,proteus and legionella

ANTI-TUBULAR ACTION:

Tuberculocidal :treatment for tuberculosis
Acts on intra and extracellular organism and drug resistant organism hence called - STERILISING AGENT
Inhibit DNA dependent RNA synthesis if used alone it develops drug resistance

Rifampicin

Bind with beta subunit of DNA dependent RNA polymerase

Inhibition of MRNA synthesis

Tuberculocidal effect

PHARMACOKINETICS:

1)ABSORPTION:Given orally

2)DISTRIBUTION:Penetrate cavities,caseous masses,placenta and meninges

3)METABOLISM :Liver

4)EXCRETION:Bile and urine

T 1/2 : 2 hours

INTERACTION:

Its a microsomal enzyme inducer ,hence can result in drug interaction
Enhance own metabolism as well as other drug like warfarin ,oral contraceptive ,corticosteroid.

ADVERSE EFFECT:

1)Hepatotoxicity :Can cause hepatitis

2)Abdominal syndrome: Nausea,vomiting,abdominal cramp

3)Flu like syndrome:Fever,body ache ,chills,hemolytic anemia

4)Cutaneous syndrome :Flushing,redness,watering of eye

5)Central nervous system symptom: Head ache ,drowsiness,ataxia ,peripheral neuropathy,confusion .

6)Hypersensitivity reaction : Fever,rashes ,urticaria,nephritis.

7)Staining of secretion:Red man syndrome .

USES:

1)Treatment of tuberculosis and atypical mycobacterial infection

2)Leprosy

3)Prophylaxis of h.influenza and meningococccal meningitis

4)Brucellosis :Rifampicin +Doxycycline

THANK YOU

STENCILDENT