DAY IN MY LIFE OF THROMBUS /FATE OF THROMBUS?

-

                            FATE OF THROMBI

Lets  have a sneak peak of how thrombi(blood clot) usually spends its precious time in our body.

Either of these 4 jobs is what thrombi usually does :

RESOLUTION,ORGANISATION ,PROPOGATION AND THROMBOEMBOLISM .

STUDENTS CORNER:

Before getting into the topic we must understand a few terminologies to get a picture of how thrombus spends its day: firstly what is Thrombosis's a process of formation of solid mass in circulation from flowing blood .

  • Mass itself is known  as thrombus.
  • Progression of thrombus is what is meant by fate of thrombus.
If the question is about thrombosis then we need to give short introduction of THROMBOCYTE ,thrombus, thrombosis etiopathogenesis, Virchow's triad,  and then conclude with the fate of thrombus.


RESOLUTION/DISSOLUTION:

  • Thrombus activate fibrinolytic system to release plasmin ,this plasmin dissolve the thrombus which results in RESOLUTION 
  • Small venous thrombi undergoes complete lysis
  • Large thrombi may not be dissolved 
  • The fibrinolytic activity is usually accentuated by UROKINASE,STREPTOKINASE.






ORGANISATION:

  • If thrombus is not removed it starts getting organized 
  • Phagocytic cells such as neutrophils and macrophages begin to phagocytose fibrin and cell debris 
  • Leucocytes and endothelial cells liberate proteolytic enzymes which start digesting coagulum.
  • Capillaries grow into the thrombus, Fibroblast invades thrombus thus fibrovascular granulation tissue is formed which subsequently becomes dense and less vascular and is covered over by endothelial cells
  • This way thrombus is excluded from vascular lumen and is made part of vessel wall
  • The new vascular channel in it may re-establish the blood flow by recanalization
  • This fibroses thrombus may also undergo hyalinization and calcification 











PROPAGATION:

  • The thrombus may enlarge in size due to more and more deposition from the constituents of flowing blood 
  • This might ultimately results in obstruction of vessel wall.





THROMBOEMBOLISM 

  • Thrombi in its initial stage and infected thrombi are quite friable and may get detached from the vessel wall
  • These are released in part or completely in blood stream as emboli which produce effect according to its site of lodgment.





CONCLUSION:

Vanakam my dear stencildent family here in this post we have just seen a birds view of fate of thrombus /day in its life but to know about its etiopathogenesis,virchows triad then do let me know in the comment section below as that would greatly motivate me to post more content .

                                          Thank you 

CONTACT DETAILS:

EMAIL:stencildent@gmail.com

Instagram:stencildent 

AUTHOR :

DR.AKARNA.R

Comments

Post a Comment

Popular posts from this blog

Sterilization technique in microbiology

-
Image
HELLO! DOCTOR VANAKAM, I hope you all are doing good today we will be discussing sterilization various methods of sterilization, about dry heat sterilization and moist heat sterilization along with different methods employed, and what are the materials to be placed in this method in detail about autoclave its principle, working and of course uses. As I have had already informed you all through my previous post on the contribution of Louis Pasteur and Koch postulates if we haven't checked it out yet do check it out using this link   https://www.stencildent.com/2020/07/contributions-of-louis-pasteur-and-koch.html  wherein I would explain the importance for the need of the HOUR and always to sterilize things to and from the patients and also get geared up for the next post on SHOCK wherein I would cover the definition, types, classification along with etiology, pathogenesis, flow chart, the complication of septic shock in detail so now without any further ado lets get started. STERILI
Read more

STAGES AND STEPS IN TOOTH PREPARATION

-
Image
                      STAGES AND STEPS IN                                        TOOTH  PREPARATION                 TOOTH PREPARATION INVOLVES 2 STAGES  1) INITIAL TOOTH PREPARATION:    OUTLINE FORM AND INITIAL DEPTH PRIMARY RESISTANCE FORM  PRIMARY RETENTION FORM CONVENIENCE FORM 2) FINAL TOOTH PREPARATION  REMOVAL OF REMAINING CARIES PULP PROTECTION SECONDARY RESISTANCE AND RETENTION FORM FINISHING OF EXTERNAL WALL FINAL PROCEDURE OF CLEANING AND INSPECTING  Each stage and step is explained in detail please refer to above notes . note:please do not  download and share all rights are reserved to stencildent.
Read more

Hypersensitivity microbiology notes

-
Image
                          HYPERSENSITIVITY   hello, doctor vanakam, I hope you all are doing good, as intimated through the last post on anaerobic culture method  https://www.stencildent.com/2020/08/anaerobic-culture-methods-microbiology.html  if u haven't checked it out do read using this link without any further ado lets get started. CONTENTS: 1)Definition 2)Classification 3)type 1 hypersensitivity reaction a)1st exposure b)2nd exposure c)mediators of reaction d)late-phase reaction 4)type 4 hypersensitivity 5)treatment  1)DEFINITION: It refers to a condition in which immune response results in excessive reaction leading to tissue damage, disease, or even death in a sensitised host. 2) CLASSIFICATION: Coomb and gel classification in 1963 into type 1 to 4  Type 1,    type 2, type 3       : They depend on the interaction of antigen with humoral antibodies They are the immediate-type reaction  type 4 : They are mediated by t lymphocyte Delayed-type of hypersensitive reaction 3)TYPE 1
Read more