NSAID -PROPIONIC ACID DERIVATIVE DRUG (IBUPROFEN),ACETIC ACID DERIVATIVE (KETOROLAC),FENAMATE DRUG(MEPHENAMIC ACID) PHARMACOLOGY NOTES

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 NON -STEROIDAL INFLAMMTORY DRUG

STUDENTS CORNER:

Hello VANAKKAM!,my dear stencildent family members this is a continuation of previous blog on introduction to non-steroidal anti inflammatory drug where in we learnt classification, mechanism of action of NSAID in detail along with a short notes on ASPIRIN if we haven't learnt about it yet then do click on the link to NSAID -PART 1 learn more. Now lets get inside our content on propionic acid derivative drug-ibuprofen ,acetic acid derivative drug -ketorolac and fenamate derivative mephenamic acid. 

PROPIONIC ACID DERIVATIVE :

IBUPROFEN

  • Better tolerated alternative to aspirin ,safest NSAID 
  • Antiplatelet  action is short lasting 
  • Weaker anti-inflammatory drug

USES:

  • Analgesic ,anti-pyretic
  • Rheumatoid arthritis
  • Tooth extraction(aspirin +codeine)
  • Soft tissue injury

ADVERSE EFFECTS :

  • Nausea
  • Vomiting
  • CENTRAL NERVOUS SYSTEM: Headache ,dizziness, blurring of vision ,rash ,itching 

PHARMACOKINETICS AND INTERACTION:

  • ABSORPTION-Well absorbed orally
  • DISTRIBUTION-90% plasma protein bound
  • METABOLISM-liver 
  • EXCRETION-urine ,bile 










FENATE DERIVATIVE :

MEPHENAMIC ACID 

  • Analgesic
  • Anti-pyretic
  • Week anti-inflammatory drug
  • Inhibit cyclooxygenase and prostaglandin action

PHARMACOKINETICS:

  • ABSORPTION-Oral is slow but almost complete
  • DISTRIBUTION-highly bound to plasma
  • METABOLISM- partly metabolized
  • EXCRETION-urine, bile

ADVERSE EFFECT :

  • Diarrhoea
  • Epigastric distress

INDICATION:

  • Analgesic in muscle ,joint ,soft tissue 








ACETIC ACID DERIVATIVE :

KETOROLAC 

  • Analgesic
  • Modest -anti-inflammatory 
  • Does not react with opioid receptor ,free of side effect
  • Inhibit prostaglandin synthesis

USE:

  • Postoperative dental pain
  • Musculoskeletal pain








PHARMACOKINETICS:

  • ABSORPTION-Rapid in oral  and intramuscular route 
  • DISTRIBUTION-plasma bound
  • METABOLISM-glucuronidation pathway 
  • EXCRETION-60% unchanged in urine 

ADVERSE EFFECT:

  • Nausea
  • Abdominal pain
  • Ulceration
  • loose stool
  • Drowsiness




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