Dystropic calcification :Pathogenesis,morpholgy ,histology

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 DYSTROPHIC CALCIFICATION 

  • Pathologic calcification is abnormal tissue deposition of calcium salts together with smaller amounts of iron ,magnesium and other mineral salts
Its of two forms :
  1. Dystrophic
  2. Metastatic
Dystrophic calcification :
  • When deposition occurs locally in dying tissue
  • It occurs despite normal serum level of calcium and in the absence of derangement in calcium metabolism
Occur in :
  • Area of necrosis
  • Advanced atherosclerosis
  • Damaged heart valve
  • Dead parasite
  • Cancer

Students corner : To learn more about pathogenesis of atherosclerosis do click on this link to learn more.








Pathogenesis:
  • Final step if fomrtaion of crystalline calcium phosphate 
INITIATION:
  • Membrane process calcium concentration bind to phospholipid present in membrane ,phosphatase generate phosphate group
 





PROPAGATION:
  • Cycle of calcium binding phosphate generating micro crystal propagate lead to more calcium deposition 






MORPHOLOGY :
  • Calcium salts appear macroscopically fine ,white granules or clum ,gritty deposits
HISTOLOGY:
  • On Hand E stain ,
  • Calcium salts:basophilic ,amorphous ,granular apperance
  • They can be intercellular ,extracellular 



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