ODONSETRON- ANTI EMETIC DRUG/MECHANISM OF ACTION /PHARMACOKINETICS AND SIDE EFFECTS

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                             ODONSETRON 

  • Pro type of anti-emetic drug
  • Controls cancer chemotherapy /radiotherapy ,drug induced vomiting.








MECHANISM OF ACTION:

  • It blocks depolarization of 5 HT through 5-HT3 receptor on vagal  afferent in gastro intestinal tract.
  • Cytotoxic drugs/chemotherapy causes cellular damage there by induce vomiting ,thereby release of mediator of 5-HT from intestinal mucosa,activation of vagal afferent in gut and sends emetogenic impulse to NTS.

  • Odonsetron blocks emetogenic impulses both at peripheral and central relay 






PHARMACOKINETICS:

  • Oral bio availability :60-70%
  • Eliminated in urine ,faceces

SIDE EFFECTS :

  • Headache
  • Mild constipation
  • Rashes 
  • Allergic reaction 



CONCLUSION:

Hi stencildent family hope you all liked this short notes on odonsetron if it helped you learn then do let me know in the comment section below as this would motivate me to post more such content .
                                  Thank you 



NOTE: pharmacology notes are for purely educational purposes only ,kindly do not consume without consulting doctor .



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