STENCILDENT

  RIFAMPICIN : Its a semi-synthetic derivative of Rifamycin  1st line drug used in tuberculosis  Rifampicin is bactericidal to M.tuberculosis,M.leprae Inhibits most gram positive and gram negative bacteria like staphylococcus aureus,N.meningitidis,E.coli,klebsiella,pseudomonas,proteus and legionella ANTI-TUBULAR ACTION: Tuberculocidal :treatment for tuberculosis  Acts on intra and extracellular organism and drug resistant organism hence called - STERILISING AGENT  Inhibit DNA dependent RNA synthesis if used alone it develops drug resistance                                                    Rifampicin             Bind with beta subunit of DNA dependent RNA polymerase                                          Inhibition of MRNA synthesis                                            Tuberculocidal effect PHARMACOKINETICS: 1)ABSORPTION:Given orally 2)DISTRIBUTION:Penetrate cavities,caseous masses,placenta and meninges 3)METABOLISM :Liver 4)EXCRETION:Bile and urine  T 1/2 : 2 hours  INTERACT

 LEUKOPLAKIA  POTENTIALLY MALIGNANT DISORDER :  R isk of malignancy being present in a lesion or condition either during the time of initial diagnosis or at future date  PRECANCEROUS LESION :  Benign morphological altered tissue in which cancer is more likely to develop than its normal counterpart : leukoplakia  Erythroplakia  Tobacco pouch keratosis  Palatal lesion in reverse smokers  PRECANCEROUS CONDITION :  Generalized state or a disease which can be associated with greater than  normal risk of cancer development  OSMF Lichen planus  Epidermolysis bullosa  LEUKOPLAKIA :  White plaque of questionable risk having excluded (other)known disease or disorder that carry no risk for cancer  PLAQUE-  Raised lesion that are greater than 1 cm in diameter ,they are essentially large papules  PAPULE:  Lesion raised above skin or mucosal surface that are smaller than  1 cm in diameter  WHO DEFINITION : Non scrapable white patch or plaque that cannot be characterized clinically or pathologically

 CRUSH SYNDROME  INTRODUCTION : It is due crushing of muscles causing : Extravasation of blood Release of hemoglobin into circulation leading to acute tubular necrosis and acute renal failure CAUSES ; Road traffic accident  Earthquake Mining ,industrial accident  Air crash Tension increases in muscle that results in increased ischemic damage  3 days :urine discolored,scanty  Life threatening  EFFECTS : Renal failure  Toxemia,septicemia Gas gangrene  Disability with extensive tissue loss TREATMENT : Tension in muscle compartment is relieved by placing multiple ,parallel,deep incision in limb Mannitol is given to improve urine output Alkalisation of urine is done using sodium citrate /sodium bicarbonate  Hemodialysis is done - life saving procedure  Other measures : Oxygen therapy  Antibiotics Blood transfusion  Bladder catheterization  AIM OF THIS POST : Hello stencildent family ,the title is definitely not a click bait it is clearly not related with CRUSH !The aim of this post is to gi

  BURNS BURN is a wound in which there is coagulative necrosis of the tissue  Burns never occur at temperature less than 44 degree celsius  Scald is a burn but caused by moist heat  TYPES: 1)THERMAL :-Flame burns,scald burn  2)ELECTRICAL 3)CHEMICAL RULE OF 9 IN BURNS : Pathology of burns are divided into : 1)Local changes: 2)Systemic changes  1)Local changes : Severity of burn Extent of burn Vascular changes Infection SEVERITY OF BURN: Microscopic destruction of the superficial layers of the epidermis Desquamated within few days  No scarring EXTENT OF BURN : Length and width of burn is expressed by percentage of total surface area displaying either 2nd or 3rd degree burn,extent estimated by WALLACE RULE OF NINES  ANATOMIC AREA                                               PERCENTAGE OF BODY SURFACE  Head ,face and neck                                                    9%  right upper extremity                                                 9% left upper extremity                     

  SYPHILIS  SYPHILIS is a world wide chronic infection produced by treponema pallidum  History :christopher columbus and his crew returns from the new world possibly carrying syphilis Global epidemiology:15-49 years old- 6 million new cases each year Incidence decreased after penicillin Male is to female ratio is 1 is to 1 Fetal ,neonatal deaths- 3,00,000  ETIOLOGY: Treponema pallidum :gram positive ,motile ,spirochete and is pathogenic to human  ROUTE OF TRANSMISSION: Sexual contact  Vertical transmission  (mother to foetus) TYPES: 1)CONGENITAL  2)ACQUIRED : PRIMARY,SECONDARY,TERTIARY  1)CONGENITAL SYPHILIS : Transmitted to offspring only infected mother and not inherited  Totally preventable  Recognised if treatment with antibiotic is begun in infected pregnant women before 4 months of pregnancy  STIGMATA OF CONGENITAL SYPHILIS: 1)Head: Frontal bossing 2)Nose:Saddle nose 3)Eyes:Interstitial keratitis 4)Oropharynx;HUTCHINSON'S TRIAD  HYPOPLASIA OF INCISOR -screw driver shaped inci

  SEBACEOUS CYST  INTRODUCTION: SYNONYMS: EPIDERMOID CYST ,WEN  Etiology: acquired -retention cyst ,sebaceous cyst -obstruction  leads to accumulation of sebaceous material  Site:  Face Scalp Scrotum Back It does not occur in palm and sole cause sebaceous glands are absent  CLINICAL FEATURES: AGE:Early adulthood,middle age  Slow growing Shape:Hemispherical,Spherical  Central keratin filled- punctum indicate blockage of duct ,dark spot  20-30% cases punctum may not be seen  Surface :smooth,round border  Consistency :soft and putty,non-tender Sign of moulding Sign of indentation :pitting on pressure over the swelling Swelling mobile,except at the site of punctum Bony defect -absent Multiple sebaceous cyst may be associated with gardner syndrome TREATMENT: Incision and avulsion of cyst with the wall During dissection,cyst wall ruptures ,care should be taken to excise cyst wall ,cause there can be recurrence Small -excised with skin COMPLICATION: INFECTION: Injury,scratch may lead  to absc

  PERITONSILLAR ABSCESS ( QUINSY) 1)INTRODUCTION: TONSIL-Subepithelial aggregation of lymphoid tissue which forms a part of waldeyer's ring Its ovoid in shape Situated in lateral wall of oropharynx QUINSY- Collection of pus in peritonsillar space between capsule and superior constrictor muscle 2)ETIOLOGY: As a sequelae of acute tonsillitis De novo  Causative organism :  Streptococcus pyogenes Staphylococcus aureus  Anaerobic organism   3)MECHANISM : One of the crypts or crypta magna gets filled